
Ionis Pharma (IONS) Stock Forecast & Price Target
Ionis Pharma (IONS) Analyst Ratings
Bulls say
Ionis Pharmaceuticals ended the fourth quarter of 2025 with $2.67 billion in cash and equivalents, reflecting growth from $2.24 billion at the end of the third quarter, indicating strong financial health. The company anticipates that revenue growth will outpace operational expenses in 2026, with notable contributions from its launches, particularly Tryngolza and Wainua, which achieved significant quarter-over-quarter revenue increases, showcasing strong market demand. Additionally, Ionis has raised its peak sales estimate for Tryngolza to $4.5 billion by 2036, which underscores the company's robust growth trajectory and positions it favorably ahead of a catalyst-rich 2026.
Bears say
Ionis Pharmaceuticals is facing a negative financial outlook due to anticipated revenue declines for its new drug Tryngolza, as pricing is expected to decrease from rare disease levels to more competitive rates for a broader indication. The company has accumulated significant losses and does not foresee profitability for several years, with projected total revenues of $800-825 million falling short of the consensus estimate of $914 million and a non-GAAP operating loss expected to reach $500-550 million, exceeding the consensus loss of $399 million. Additionally, ongoing risks, including potential delays in approvals, slower market uptake, and increasing competition in the HAE market, further undermine Ionis's financial stability and growth prospects.
This aggregate rating is based on analysts' research of Ionis Pharma and is not a guaranteed prediction by Public.com or investment advice.
Ionis Pharma (IONS) Analyst Forecast & Price Prediction
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