
Ionis Pharma (IONS) Stock Forecast & Price Target
Ionis Pharma (IONS) Analyst Ratings
Bulls say
Ionis Pharmaceuticals has raised its 2025 financial guidance, projecting total revenue between $875 million and $900 million, an increase from the previous estimate of $825 million to $850 million, driven by strong product performance, particularly from its drug Tryngolza, which generated $32 million in the third quarter of 2025. Additionally, the company reported positive data regarding its product candidates, increasing the penetration projections for Wainua in ATTR-CM from 15% to 20%, which bodes well for future revenue growth. The optimistic outlook is further supported by the company's commitment to innovation in drug development and strategic regulatory submissions, enhancing the potential for upward revisions in future earnings.
Bears say
Ionis Pharmaceuticals is facing significant financial challenges, as evidenced by accumulated losses and an expectation of no profitability for several years, which raises concerns regarding the sustainability of its business model. The company's cash and equivalents declined slightly from $2.3 billion to $2.24 billion within a single quarter, indicating potential liquidity issues amid ongoing financial losses, including a reported GAAP net loss of $129 million for the latest quarter. Additionally, there are multiple risks impacting the future performance of its drugs, including potential erosion of Spinraza’s market share due to competitive pressures, delays in regulatory approvals, and uncertainties regarding the effectiveness of treatments targeting cardiovascular outcomes.
This aggregate rating is based on analysts' research of Ionis Pharma and is not a guaranteed prediction by Public.com or investment advice.
Ionis Pharma (IONS) Analyst Forecast & Price Prediction
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