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SYRE
Volume: 110.4K
SYRE logo

SYRE Stock Forecast & Price Target

SYRE Analyst Ratings

Based on 4 analyst ratings
Strong Buy
Strong Buy 75%
Buy 25%
Hold 0%
Sell 0%
Strong Sell 0%

Bulls say

Spyre Therapeutics Inc. is focused on advancing treatment options for inflammatory bowel disease (IBD) by developing innovative biopharmaceutical products, which is underscored by their efforts to combine antibody engineering with precision medicine. The company has demonstrated significant efficacy in their product SPY003, which can reduce the injection burden to as infrequent as every six months while offering the potential for enhanced therapeutic outcomes when used in combination regimens for IBD. Furthermore, their lead product, tulisokibart, has shown over four-fold greater target engagement compared to existing therapies, indicating a strong competitive position in the market and potential for substantial clinical and commercial success.

Bears say

Spyre Therapeutics Inc faces significant challenges due to the high immunogenicity rates (ranging from 72-100%) associated with its discontinued bispecific antibodies, which raises concerns about the safety and efficacy of its product pipeline. In contrast, competing products, such as JNJ-4804, have demonstrated much lower immunogenicity rates of 6% in clinical trials, highlighting a potential competitive disadvantage for Spyre. Additionally, the difficulty in optimizing for convenience using existing, more effective therapeutic options may hinder the company's ability to attract investment and market share in the evolving IBD treatment landscape.

SYRE has been analyzed by 4 analysts, with a consensus rating of Strong Buy. 75% of analysts recommend a Strong Buy, 25% recommend Buy, 0% suggest Holding, 0% advise Selling, and 0% predict a Strong Sell.

This aggregate rating is based on analysts' research of Spyre Therapeutics Inc and is not a guaranteed prediction by Public.com or investment advice.

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FAQs About Spyre Therapeutics Inc (SYRE) Forecast

Analysts have given SYRE a Strong Buy based on their latest research and market trends.

According to 4 analysts, SYRE has a Strong Buy consensus rating as of Dec 16, 2025. This rating is provided by third-party analysts and is not investment advice from Public.com.

Wall Street analysts have set a price target of $55.50, reflecting a 0.00% increase from the current stock price.

Financial analysts have set a price target of $55.50, indicating a 0.00% increase from the current stock price, but ratings and forecasts are frequently updated based on market conditions, earnings reports, and industry trends. This prediction is provided by third-party analysts and is not investment advice from Public.com.

Spyre Therapeutics Inc (SYRE)

Volume: 110.4K

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