
PLRX Stock Forecast & Price Target
PLRX Analyst Ratings
Bulls say
Pliant Therapeutics Inc's primary product candidate, bexotegrast (PLN-74809), demonstrates promising efficacy in treating idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC), positioning it as a significant asset for the company. The novel dual blockade mechanism targeting integrins αvβ8 and αvβ1 is expected to enhance immune activation while potentially improving safety by minimizing systemic TGF-β side effects. The favorable evidence observed in early trials suggests that optimizing bexotegrast through additional dose-ranging studies could further support its development and market potential within the fibrosis treatment landscape.
Bears say
Pliant Therapeutics Inc. has recently terminated its BEACON-IPF Phase 2b trial for bexotegrast due to safety concerns, specifically an unexpected lower rate of IPF-related adverse events in the placebo group, signifying potential challenges for the drug's development. The cessation of this key trial raises significant concerns about the viability of bexotegrast as a treatment option, particularly as the company's pipeline appears limited with no clear catalysts expected in the near term. Additionally, Pliant reported a net loss of $49.7 million for Q4 2024, reflecting ongoing financial burdens amidst increasing uncertainty regarding the future of its only primary product candidate.
This aggregate rating is based on analysts' research of Pliant Therapeutics and is not a guaranteed prediction by Public.com or investment advice.
PLRX Analyst Forecast & Price Prediction
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