
Alnylam Pharmaceuticals (ALNY) Stock Forecast & Price Target
Alnylam Pharmaceuticals (ALNY) Analyst Ratings
Bulls say
Alnylam Pharmaceuticals demonstrated robust financial performance in 2025, with combined net product revenues reaching approximately $2.987 billion, a remarkable 81% increase year-over-year, thereby surpassing original revenue guidance by over $800 million. The company's successful growth in its Rare franchise—totaling around $500 million for the year—reflects strong demand for its therapeutic products such as GIVLAARI and OXLUMO, alongside improved gross margins and significant operating leverage expansion. Furthermore, Alnylam's strategic investments in research and development are expected to drive continued scale in its programs, substantiated by anticipated 26% year-over-year growth in combined R&D and SG&A expenses from 2025 to 2026, positioning the company well for future advancements in RNAi therapeutics.
Bears say
Alnylam Pharmaceuticals is facing a challenging financial outlook, primarily due to a forecasted decline in growth for 1Q26 attributed to transitory factors, which include international revenue reductions and pricing adjustments for AMVUTTRA. The company anticipates a significant drop in collaboration and royalty revenues in 2026, projected between $400 million and $500 million, down from approximately $727 million in 2025, which was bolstered by a one-time milestone payment. Additionally, ongoing gross-to-net dynamics coupled with tiered royalty escalations are expected to contribute to a mid-single-digit net price decline for AMVUTTRA, further straining revenue streams.
This aggregate rating is based on analysts' research of Alnylam Pharmaceuticals and is not a guaranteed prediction by Public.com or investment advice.
Alnylam Pharmaceuticals (ALNY) Analyst Forecast & Price Prediction
Start investing in Alnylam Pharmaceuticals (ALNY)
Order type
Buy in
Order amount
Est. shares
0 shares