Prothena

Prothena Corp. Plc is a clinical-stage neuroscience company. It focuses on the discovery and development of novel therapies to change the course of devastating diseases. The firm’s clinical pipeline includes both wholly-owned and partnered programs being developed for the potential treatment of diseases including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and other neurodegenerative diseases. The company was founded in December 1969 and is headquartered in Dublin, Ireland.

Earnings data Q4 2020

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Prothena reports robust earnings, advances Alzheimer's treatments with promising results

Prothena's Q4 2022 earnings call highlighted strong financial performance, pipeline advancements in neurodegenerative diseases, and promising results in key programs like PRX012 and Birtamimab.
Challenges include navigating reimbursement changes, dosing complexities, and ensuring accelerated approval pathways for Alzheimer's treatments.
Opportunities lie in leveraging financial strength for pipeline expansion, upcoming data releases, innovative treatment approaches, and establishing leadership in niche disease areas.
Overall, Prothena's strategic focus on innovative therapies and deep understanding of disease mechanisms position the company for continued growth and clinical success.

Prothena reports robust financials and promising clinical advancements in Q4

Prothena's Q4 2023 earnings call highlighted strong financials, progress in key clinical programs, and promising results in movement disorder studies.
While facing challenges in patient enrollment and dose optimization, the company's focus on specialized therapies and patient-centric development positions it well for future growth.
Opportunities lie in optimizing dosing strategies, enhancing treatment efficacy, and leveraging exposure response data to drive innovation and improve therapeutic outcomes.

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Prothena Corp. Plc is a clinical-stage neuroscience company, which engages in the discovery and development of novel therapies to change the course of devastating diseases. The firm’s clinical pipeline includes both wholly owned and partnered programs being developed for the potential treatment of diseases including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and other neurodegenerative diseases. The company was founded in December 1969 and is headquartered in Dublin, Ireland.

DUBLIN--(BUSINESS WIRE)---- $PRTA #AAIC2023--Prothena today shared data on 3 investigational product programs for the treatment and prevention of Alzheimer's disease at AAIC 2023.

Prothena Presents New Research in the Treatment of Alzheimer's Disease at Alzheimer's Association International Conference® 2023 (AAIC®)

DUBLIN--(BUSINESS WIRE)---- $PRTA #AAIC2023--Prothena today announced participation in the Alzheimer's Association International Conference® 2023 (AAIC®) being held July 16-20, 2023.

Prothena to Present New Data from Alzheimer's Disease Programs at Alzheimer's Association International Conference® 2023 (AAIC®)

Prothena (PRTA) will receive $55 million from Bristol Myers Squibb for an exclusive worldwide license to PRX005, designed for the potential treatment of Alzheimer's disease.

Prothena (PRTA) Alzheimer's Disease Drug Licensed by BMY

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena today announced that Bristol Myers Squibb exercised its option to obtain exclusive worldwide commercial rights for PRX005.

Prothena Announces Bristol Myers Squibb Opt-in for Worldwide Rights of PRX005, a Novel Anti-MTBR-Tau Antibody

DUBLIN--(BUSINESS WIRE)---- $PRTA #amyloidosis--Prothena today announced the publication of the Phase 3 VITAL clinical trial in Blood, a journal of the American Society of Hematology (ASH).

Prothena Announces Phase 3 VITAL Clinical Trial Results Published in Blood Showing Survival Benefit in Patients with Mayo Stage IV AL Amyloidosis Treated with Birtamimab

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena today announced that it will participate in a fireside chat at the Jefferies Healthcare Conference on June 8, 2023 at 1:00 PM ET.

Prothena to Participate in Jefferies 2023 Healthcare Conference

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena announced today the appointment of Dr. Billy Dunn, the founding Director of the Office of Neuroscience, CDER, to its Board of Directors.

Prothena Announces Appointment of Billy Dunn, M.D., to its Board of Directors

Prothena's recent collaboration with Walgreens is expected to drive recruitment for Prothena's ongoing ASCENT-2 safety and tolerability trial of PRX012. PRX012, an anti-amyloid beta antibody, has shown superior binding and clearance of toxic Aβ species compared to other approved and investigational molecules in preclinical studies.

Prothena Biosciences' Unique Approach To Protein Misfolding Could Be The Future

Prothena (PRTA) reports a wider loss in the first quarter. The company makes considerable pipeline progress.

Prothena (PRTA) Q1 Earnings and Revenues Miss Estimates

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena today reported financial results for the first quarter of 2023 and provided business highlights.

Prothena Reports First Quarter 2023 Financial Results and Business Highlights

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena today announced that it will report its first quarter 2023 financial results on Thursday, May 4, 2023.

Prothena to Report First Quarter 2023 Financial Results on May 4

Prothena (PRTA) doesn't possess the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.

Analysts Estimate Prothena (PRTA) to Report a Decline in Earnings: What to Look Out for

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena today announced that members of its management team will participate in a fireside chat at the 2023 Bank of America Healthcare Conference.

Prothena to Participate in 2023 Bank of America Healthcare Conference

Walgreens

DEERFIELD, Ill. & DUBLIN--(BUSINESS WIRE)--Walgreens and Prothena today announced a collaboration to accelerate patient identification and recruitment for Prothena's ongoing ASCENT-2 multiple ascending dose clinical trial evaluating the safety and tolerability of PRX012, a potential best-in-class anti-amyloid beta antibody under development for the treatment of Alzheimer's disease.

Walgreens and Prothena Partner to Increase Access and Enrollment in Alzheimer's Disease Clinical Trial

Prothena (PRTA) surges 29% in the past one year as investors are optimistic on its promising Alzheimer's Disease pipeline.

Prothena (PRTA) Gains 29% in One Year: Will the Momentum Continue?

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena Presents New Preclinical Data Supporting Best-in-Class Profile of PRX012, a Next-Generation Anti-Amyloid Beta Antibody, at AD/PD 2023

Prothena Presents New Preclinical Data Supporting Best-in-Class Profile of PRX012, a Next-Generation Anti-Amyloid Beta Antibody, at AD/PD 2023

DUBLIN, Ireland--(BUSINESS WIRE)---- $PRTA #prothena--Prothena announced today that members of its senior management team will participate in a fireside chat at Stifel 2023 Virtual CNS Days on March 28 .

Prothena to Participate in Stifel 2023 Virtual CNS Days

DUBLIN--(BUSINESS WIRE)---- $PRTA #ADPD2023--Prothena announced broad participation at AD/PD 2023 highlighting leadership in advancing treatments for Alzheimer's and Parkinson's disease

Prothena to Highlight Next Generation Treatments for Alzheimer's and Parkinson's Disease at the AD/PD 2023 Meeting

Prothena (PRTA) reports better-than-expected results for the fourth quarter. The company makes considerable pipeline progress.

Prothena (PRTA) Q4 Earnings and Revenues Beat Estimates

Prothena Corporation plc (NASDAQ:PRTA ) Q4 2022 Earnings Conference Call February 23, 2023 4:30 PM ET Company Participants Eric Endicott - Senior Vice President, Corporate Affairs and Communications Gene Kinney - President and Chief Executive Officer Hideki Garren - Chief Medical Officer Tran Nguyen - Chief Financial Officer and Chief Strategy Officer Wagner Zago - Chief Scientific Officer Conference Call Participants Michael Yee - Jefferies Neena Bitritto-Garg - Citi Charles Duncan - Cantor Fitzgerald Jay Olson - Oppenheimer Brian Abrahams - RBC Capital Markets Jason Butler - JMP Securities Operator Good afternoon. My name is Audra and I will be your conference operator today.

Prothena Corporation plc (PRTA) Q4 2022 Earnings Call Transcript

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena Corporation plc today reported financial results for the 4th quarter and full year 2022.

Prothena Reports Fourth Quarter and Full Year 2022 Financial Results, and Provides Financial Guidance and Business Highlights

DUBLIN--(BUSINESS WIRE)---- $PRTA #prothena--Prothena Corporation plc announced that it will report its fourth quarter and full year 2022 financial results on February 23, 2023.

Prothena to Report Fourth Quarter and Full Year 2022 Financial Results on February 23, 2023

DUBLIN--( BUSINESS WIRE )--Prothena Corporation plc (NASDAQ:PRTA), a late-stage clinical biotechnology company with a robust pipeline of novel investigational therapeutics built on protein dysregulation expertise, today announced that in connection with hiring a new employee, the compensation committee of the Company's board of directors granted the individual hired by the Company an option to purchase 85,000 ordinary shares of the Company. The option has an exercise price per share equal to $53.67, which was the closing trading price on February 1, 2023, the date of the grant. The option will vest over four years, with 25% of the underlying shares vesting on the one-year anniversary of the date of grant and 1/48th of the underlying shares vesting monthly thereafter over 36 months. The option was granted pursuant to the Company's 2020 Employment Inducement Incentive Plan, which was approved by the Company's board of directors under Rule 5635(c)(4) of The Nasdaq Global Market for equity grants to induce new employees to enter into employment with the Company.

Prothena Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

DUBLIN--( BUSINESS WIRE )--Prothena Corporation plc (NASDAQ:PRTA), a late-stage clinical biotechnology company with a robust pipeline of investigational therapeutics built on protein dysregulation expertise, today announced positive topline Phase 1 single ascending dose (SAD) study results for PRX005, a potentially best-in-class investigational tri-epitopic antibody for the treatment of Alzheimer's disease that specifically binds with high affinity to the R1, R2, and R3 repeats within the microtubule binding region (MTBR) of tau and targets both 3R and 4R tau isoforms. PRX005 is one of three programs in the global neuroscience research and development collaboration between Prothena and Bristol Myers Squibb.

Prothena Reports Topline Phase 1 Single Ascending Dose Study Results of PRX005, a Novel Anti-MTBR-Tau Antibody for the Potential Treatment of Alzheimer's Disease

Prothena (PRTA) surges 88% in the last six months as investors are optimistic on its promising Alzheimer???s Disease pipeline.

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